The Respiratory Failure and Mechanical Ventilation Conference (RF&MV) took place in Berlin from 13 to 15 February. This conference allowed healthcare professionals to update their knowledge in the field of artificial ventilation. This technique is commonly used in intensive care units or at home for long-term treatment 1,2.
Performances noticed by the RF&MV scientific committee
For many years, OptimHal-ProtecSom laboratory has carried out research on drug delivery in the context of mechanical ventilation. This research made it possible to develop CombiHaler® and MinimHal® spacers.
A study comparing effectiveness of these spacers to standard equipment used in mechanical ventilation circuits caught the attention of the scientific committee of RF&MV. This study (carried out by Dr. Eckes) was selected to be presented as an e-poster short talk by Dr. Vanlaeys, R&D project manager at OptimHal-ProtecSom laboratory.
Drug delivery in mechanical ventilation via MinimHal® and CombiHaler® : a proven effectiveness
Artificial ventilation is driven by a ventilator connected to the patient by a circuit. This process allows to maintain the patient’s breathing in case of insufficient respiratory capacities. Drugs can be delivered to the patient by different kinds of devices disposed in ventilation circuit (typically a T-piece or a spacer) which allow to connect a pressurized metered dose inhaler or a nebulizer.
This study showed that using CombiHaler® or MinimHal® instead of a T-piece allows to double the salbutamol inhaled dose. These results were reproducible using adult and pediatric respiratory patterns.
CombiHaler® and MinimHal® also stand out for their versatility. These spacers can be used to deliver drugs thanks to a pressurized metered dose inhaler and / or a nebulizer.
- Slutsky AS. History of Mechanical Ventilation. From Vesalius to Ventilator-induced Lung Injury. Am J Respir Crit Care Med. 2015;191((10)):1106–15. 10.1164/rccm.201503-0421PP
- Manthous, C., Tobin, MJ. A Primer on Critical Care for Patients and Their Families. 1st issued in 2001; 2017-2018 Update to be posted on www.thoracic.org/patients