The US patent for our DigitHal® technology for inhaled treatments was issued this week.
This is a big step for this project, which specifically addresses non-observance by asthmatic patients, hence allowing better support from caregivers. DigitHal® provides real-time information on the inhalation of the drug and aims to improve the method of patient administration. This new device will in fact offer a more relevant solution for taking and monitoring any inhaled treatment.
DigitHal® : two Galien Medstartup rewards
DigitHal® is consequently moving forward on its America journey as this particular project had already been twice rewarded in October 2017 during the prestigious Galien Medstartup award ceremony in New York City. Indeed, our team went back to France after winning the prizes in the categories Best collaboration with an academicpartner (in partnership with the Virginia Commonwealth University) and Best use of technologies involving patients and their health.
The US patent is therefore an important step for this technology made in Normandy.
Within the context of the COVID-19 crisis, our team focused on speeding up the production process of the TipsHaler HospitHal® sterilizable inhalation chamber so that its commercialization could be anticipated. Initially planned for the fall 2020, our teams have done their best so that medical staff and patients could benefit as soon as possible from this new efficient, practical and economical inhalation chamber made in France.
Autoclave sterilization up to 134°
This new device is undoubtedly the first inhalation chamber which accepts autoclave with such a hard cycle protocol. This performance complements the proven qualities and effectiveness of the TipsHaler® inhalation chamber.
This inhalation chamber allowing the most severe sterilization conditions, the constraint of the single patient has disappeared. The autoclave between two patients thus becomes possible up to 10 sterilizations.
TipsHaler HospitHal® in the context of the COVID-19 crisis
Nebulization induces a risk of dissemination of the COVID-19 virus through the droplets emitted within the patient’s environment. The inhalation chamber is therefore the best alternative for the administration of inhaled treatments to hospitalized patients. The need for inhalation chambers has logically greatly increased. Due to its multi-patient capacity, the sterilizable TipsHaler HospitHal® inhalation chamber offers substantial savings to a healthcare system weakened by the current crisis.
The sterilizable TipsHaler HospitHal® for fragile patients
The TipsHaler HospitHal® sterilizable inhalation chamber has also been designed for the benefit of fragile patients, including those with cystic fibrosis. It allows patients to protect themselves from infections by sterilizing the inhalation chamber, both in hospitals and on an ambulatory basis.
Within the evolving context and under the national measures implemented to ensure everyone’s safety in the COVID-19 epidemic, our teams, especially those of production, remain mobilized and united in order to ensure the production of the devices essential for medical staff and patients.
Inhalation chambers for the drug delivery in the context of mechanical ventilation
We are facing new and very specific requests for inhalation chambers from hospitals. We aim to respond positively to every case in order to provide our help and our material support to every hospitals departments concerned.
Given the risks associated with nebulizations that can disseminate COVID-19 via droplets emitted in the patient’s environment, inhalation chambers are indeed the best alternative for the administration of inhaled treatments.
Mask production in partnership with Dans Ma Culotte
Within this epidemic context, our teams quickly adapted and mobilized to help caregivers, medical staff and every workers particularly exposed to COVID-19.
We have for instance increased our partnership with the company Dans Ma Culotte which specializes in washable sanitary napkins and which we had been collaborating with since 2014. This production has been changed inside our workshops into the manufacture of masks made from anti-projections tissue, washable and reusable up to 30 times. This system, validated by our R&D team, aims to protect the most exposed people to the virus as much as possible.
Anti-mite covers: production and shipping maintained
As confinement can sometimes contributes to the exacerbation of allergics symptoms, our production of anti-mite covers and their shipment are also maintained to meet the needs of allergic patients.
The Respiratory Failure and Mechanical Ventilation Conference (RF&MV) took place in Berlin from 13 to 15 February. This conference allowed healthcare professionals to update their knowledge in the field of artificial ventilation. This technique is commonly used in intensive care units or at home for long-term treatment 1,2.
Performances noticed by the RF&MV scientific committee
For many years, OptimHal-ProtecSom laboratory has carried out research on drug delivery in the context of mechanical ventilation. This research made it possible to develop CombiHaler® and MinimHal® spacers.
A study comparing effectiveness of these spacers to standard equipment used in mechanical ventilation circuits caught the attention of the scientific committee of RF&MV. This study (carried out by Dr. Eckes) was selected to be presented as an e-poster short talk by Dr. Vanlaeys, R&D project manager at OptimHal-ProtecSom laboratory.
Drug delivery in mechanical ventilation via MinimHal® and CombiHaler®: a proven effectiveness
Artificial ventilation is driven by a ventilator connected to the patient by a circuit. This process allows to maintain the patient’s breathing in case of insufficient respiratory capacities. Drugs can be delivered to the patient by different kinds of devices disposed in ventilation circuit (typically a T-piece or a spacer) which allow to connect a pressurized metered dose inhaler or a nebulizer.
This study showed that using CombiHaler® or MinimHal® instead of a T-piece allows to double the salbutamol inhaled dose. These results were reproducible using adult and pediatric respiratory patterns.
CombiHaler® and MinimHal® also stand out for their versatility. These spacers can be used to deliver drugs thanks to a pressurized metered dose inhaler and / or a nebulizer.
The World Allergy Congress (WAC), an international conference on allergology, took place in France (Lyon) on December 12th to 14th, 2019. This event allowed many actors in the fight against allergy to update their knowledge on this pathology affecting up to 40% of the worldwide population.1
With more than 15 years of experience in dust mite covers manufacturing, the OptimHal-ProtecSom lab presented a study in the form of poster communication selected by the WAC Scientific Committee. The aim of this retrospective study was to determine and quantify the benefit from the use of dust mite covers on the life quality of allergic patients.
A significant improvement in life quality for patients who use ProtecSom dust mite covers
ProtecSom anti-mite covers are certified medical devices which form a protective barrier preventing the passage of mites thanks to their unique patented weaving process. A declarative study demonstrated the benefit of dust mite covers on the perception of allergy-related symptoms.
This study revealed a significant increase in life quality following the use of the ProtecSom dust mite covers and implementation of complementary measures to control patient’s environment. An improvement in allergy-related symptoms (nasal discharge, cough, eye inflammation, itchy skin and breathing problems) was observed in all age groups asked. The overall symptom reduction was 62%.
The 24th French Language Pneumology Congress (CPLF) took place in Paris on January 24th. This annual conference allows to more than 5,000 healthcare professionals to discuss the discoveries and innovations in the treatment of allergy and asthma.
A medical device noticed by the scientific community
Only 30% of newborns are able to inspire enough to open the inspiratory valve of valve holding chambers.1 Moreover, most of valve holding chamber have a dead volume not allowing to children under 1 year of age to inhale efficiently their treatment.2 Facing these facts, the OptimHal-ProtecSom team has developed NeonatHal®, a valve holding chamber without inspiratory valve. This prototype was introduced by Thierry Porée, the Scientific Director of OptimHal-ProtecSom, to the scientific community during a communication selected on abstract by the CPLF Scientific Committee.
Already promising results
The results are very clear, NeonatHal® use allows to double the delivery of bronchodilators at their action site. These results pave the way toward new studies aiming at determining until what age NeonatHal® offers a clear clinical benefit for the treatment of asthma.
Herbes, C. et al. Metered‐dose inhaler therapy with spacers: Are newborns capable of using this system correctly? Pediatr Pulmonol 54, 1417–1421 (2019).
Amirav, I. & Newhouse, M. T. Review of optimal characteristics of face-masks for valved-holding chambers (VHCs). Pediatr. Pulmonol. 43, 268–274 (2008).
The Aerosol Society organized its 30th DDL congress in Edinburgh from December 11 to 13.
It is a must-attend annual forum for scientists, academics, clinicians, regulatory and industry experts involved in the development of inhalation medication. On the program, five thematic sessions each with a combination of conferences by experts in the field of inhalation and by students working to advance respiratory science.
During this congress, Thierry Porée, scientific director of the OptimHal-ProtecSom Laboratory, presented at a conference our latest work on the inhalation chamber for CombiHaler® mechanical ventilation circuits. An innovation !
CombiHaler® is an inhalation chamber for mechanical ventilation. It enables the simultaneous administration of medication by a metered dose inhaler and a vibrating mesh nebulizer.
It is intended to be used in hospitals, intensive care, or home hospitalization.
Research and results of interest have been presented by the OptimHal-ProtecSom laboratory.
Heating and humidifying a mechanical ventilation circuit is needed to protect the lungs of patients under invasive respiratory assistance. However, heat and humidity reduce the dose of aerosols delivered to the patient. We assessed the impact of heat and humidity on in vitro drugs delivery using pressurized metered dose inhaler and vibrating mesh nebulizer with CombiHaler®
This work has demonstrated the advantage of using an inhalation chamber both with a vibrating mesh nebulizer and with a metered dose inhaler, in comparison with the usually used T-pieces.
It also demonstrated that switching off the heated humidifier located in a mechanical ventilation circuit during drug administration did not increase the delivered dose and that the position of the inhalation chamber in the heated and humidified mechanical ventilation circuit had an important influence on this delivered dose.
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